Nifekalant hydrochloride suppresses severe electrical storm in patients with malignant ventricular tachyarrhythmias.

نویسندگان

  • Takashi Washizuka
  • Masaomi Chinushi
  • Hiroshi Watanabe
  • Yukio Hosaka
  • Satoru Komura
  • Hirotaka Sugiura
  • Takashi Hirono
  • Hiroshi Furushima
  • Yasutaka Tanabe
  • Yoshifusa Aizawa
چکیده

BACKGROUND Some patients with an implantable cardioverter-defibrillator (ICD) suffer from burst of inappropriate multiple discharges (severe electrical storm), and because the current therapeutic options are limited, the effect of nifekalant hydrochloride, a new class III drug, on severe electrical storm was investigated in the present study. METHODS AND RESULTS Ninety-one consecutive patients treated with ICD were included in the study (M 70; mean age 58 years; left ventricular ejection fraction 45+/-15%). Severe electrical storm was defined as more than 10 ICD discharges within 1 h. During a mean follow-up period of 30+/-13 months, 41/91 (45%) patients had appropriate ICD therapy for arrhythmias and severe electrical storm occurred in 11 of them (12%) at 20+/-18 months after ICD implantation. The mean number of ICD discharges/h during severe electrical storm was 18+/-12. In 4 of 10 patients, severe electrical storm was successfully suppressed by a combination of deep sedation and beta-blocking agent; 6 other patients were refractory to this treatment, but severe electrical storm was successfully suppressed by intravenous administration of nifekalant hydrochloride with no adverse effects. CONCLUSIONS Nifekalant hydrochloride is an effective and safe treatment for severe electrical storm.

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عنوان ژورنال:
  • Circulation journal : official journal of the Japanese Circulation Society

دوره 69 12  شماره 

صفحات  -

تاریخ انتشار 2005